Autophagy and cell death
نویسندگان
چکیده
منابع مشابه
Autophagy and cell death.
Autophagy is a physiological and evolutionarily conserved phenomenon maintaining homeostatic functions like protein degradation and organelle turnover. It is rapidly upregulated under conditions leading to cellular stress, such as nutrient or growth factor deprivation, providing an alternative source of intracellular building blocks and substrates for energy generation to enable continuous cell...
متن کاملAutophagy and cell death.
Autophagy is intimately associated with eukaryotic cell death and apoptosis. Indeed, in some cases the same proteins control both autophagy and apoptosis. Apoptotic signalling can regulate autophagy and conversely autophagy can regulate apoptosis (and most likely other cell death mechanisms). However, the molecular connections between autophagy and cell death are complicated and, in different c...
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Autophagy is an evolutionarily conserved intracellular catabolic process that is used by all cells to degrade dysfunctional or unnecessary cytoplasmic components through delivery to the lysosome. Increasing evidence reveals that autophagic dysfunction is associated with human diseases, such as cancer. Paradoxically, although autophagy is well recognized as a cell survival process that promotes ...
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Cell death is a major component of developmental programs. Controlled killing of specific cells at appropriate time points is required for normal growth and shaping of organisms. However, cellular demolition can also result in a variety of pathologies that are frequently fatal, when implemented inappropriately. Delineation of cell death mechanisms has been greatly facilitated by the use of simp...
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Macroautophagy (autophagy) is a conserved cell survival pathway that catabolizes damaged proteins and organelles to maintain homeostasis and serves as a potential source of nutrients. Under basal cell conditions, cytosolic contents are sequestered by the autophagosome and ultimately delivered to the lysosome for degradation. The degradative process can in turn be upregulated in response to mult...
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ژورنال
عنوان ژورنال: Essays in Biochemistry
سال: 2013
ISSN: 0071-1365,1744-1358
DOI: 10.1042/bse0550105